SANCTUARY follows the exploits of Dr. Helen Magnus (Amanda Tapping) and her quest to protect various cryptids, legends, and abnormal animals/people with certain extraordinary powers and abilities (what most people would consider "monsters"). She heads the Sanctuary Network, which consists of large facilities known as "Sanctuaries" scattered throughout the world serving as safe havens for these "Abnormals". She is initially aided in her quest by her reluctant protégé Will Zimmerman (Robin Dunne); her intrepid, if somewhat reckless, daughter Ashley (Emilie Ullerup); the talkative geek and lycanthrope Henry Foss (Ryan Robbins), a computer and security expert; and her taciturn, Homo heidelbergensis-like assistant, played by Christopher Heyerdahl (unnamed, but listed as "Bigfoot" in the show's credits).
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